Zinc comes up in Botox conversations because botulinum toxin needs zinc to work, but whether a zinc supplement changes how long results last is emerging pilot research, not a proven promise. Here’s what’s known so far.
Say you’re looking for ways to make your Botox last, and somewhere in the search results someone mentions zinc. It sounds simple enough to try. It’s worth slowing down first.
Why does zinc come up at all?
The active part of Botox and Dysport is an enzyme that depends on zinc to do its job. That happens inside the nerve cell, and on its own it doesn’t show that you need extra zinc.
What has the research found?
A small pilot study in 2012 suggested a possible link between zinc with phytase, an enzyme that helps the body absorb zinc, and longer-lasting effects. The study wasn’t fully blinded and ended early, so it isn’t a basis for recommending a supplement. A 2014 critique raised concerns about its design, unclear dosing, and a possible conflict of interest, and called for caution.
Since then, a 2023 systematic review found only two randomized trials and concluded the evidence is insufficient to recommend zinc supplements for this purpose. A second 2023 review was more hopeful, calling zinc an interesting possibility and asking for larger trials.
Is it safe to try on my own?
Zinc supplements can cause nausea, stomach upset, and headache. High amounts over time can interfere with how your body absorbs copper, and zinc can interact with some medicines, including certain antibiotics. Talk with your doctor before starting any supplement.
What can I do to get the most from my treatment?
Share your health history, medicines, and supplements with your provider at your consultation. Follow the aftercare you’re given, and keep the follow-up visits your provider recommends, because results are temporary and vary from person to person. Ask questions at any point.
Botox and Dysport are offered by Susan Fallon, RN, on Tuesdays, and every plan starts with a consultation. You can read more in our Botox and Dysport questions and answers or contact us.
When you’re ready, call 781-235-7788 or book online.